Abstract: The article examines the problems and prospects of entrepreneurship development in Ukraine during a state of war. The main factors influencing business development in conditions of armed conflict are identified. As a result of the study, the problems of entrepreneurship development in Ukraine during a state of war were divided into several main categories: full-scale military aggression by the Russian Federation, which led to a deterioration of the security situation and risks for entrepreneurship; economic instability and reduced consumer activity; political instability and corruption, which can hinder entrepreneurship development and reduce trust in business as a whole. Statistical data on the development of enterprises are analyzed: the state and forecast indicators of entrepreneurial structures, macroeconomic indicators of the country’s economic development, and others. The main obstacles to conducting entrepreneurial activities during a state of war for entrepreneurs are researched. The negative impact of the war on the country’s economy and the entrepreneurship sector in particular is investigated, which manifests itself in a decrease in the profitability and business activity of entrepreneurial structures, a decrease in the purchasing power of the population, the loss of markets and logistical ties, a reduction in personnel, the destruction of civil and critical infrastructure, and a high level of inflation, among other things. The relocation of Ukrainian enterprises due to the armed conflict is analyzed. Directions of state policy regarding support for entrepreneurship in conditions of war, including state programs for supporting entrepreneurship in Ukraine, are discussed. Legislative changes that affect the activities of entrepreneurial structures in the country are considered. Prospective directions for entrepreneurship development in Ukraine are determined. Measures to support entrepreneurship development are proposed. It is determined that the development of entrepreneurship in Ukraine in conditions of war requires a comprehensive approach and coordinated actions by the authorities, business, and society.